The population of DeWitt City has steadily increased since 1900, primarily due to the agricultural growth in the surrounding area. It is the second largest city in Clinton County, second only to Clinton, located along the Mississippi River. It serves the western third of the county, and is a thriving agri-business center. In addition, the town has a small, industry-oriented economy.
The climate of DeWitt is typical of the "cornbelt" region. Winters average 24 degrees Fahrenheit, while summer temperatures average 73 degrees. The city's annual precipitation averages 35 inches, with a high of about 28 inches during the winter months. The climate of DeWitt City is perfect for raising livestock. Although the population has remained relatively stable, the city's economy has been facing many challenges.