In the 2016 Census, the city's population was 44,298. Twenty-one percent of its residents were under the age of eighteen. Twenty-four percent were between the ages of 25 and 44, twenty-one percent were between the ages of 45 and 64, and fourteen percent were over the age of 65. The median age of the population was 37 years. The city's gender ratio was 48.3% male to 51.7% female.
As of the 2010 Census, Louisburg had a population of 3,499. Its median household income was $27,072, making the area affluent place to live. The city has a low poverty rate, at just 1.6 percent. However, the median home value is $69,000. House values in Louisburg, KS are not so affordable; homes are cheaper in the surrounding areas.
The school system in Louisburg is part of the city's economy. The Louisburg City school district has four elementary schools and one high school. There are also numerous other educational institutions in the area. This city has a relatively high percentage of residents with a bachelor's degree or higher. Although it has a low percentage of vacancies, the Census reports that the city has a nursing home within a half-mile of its center.